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Prostate Cancer in for New Treatment Mechanism: Research
During the study, researchers Professor Wayne Tilley and Dr Lisa Butler of the University's Dame Roma Mitchell Cancer Research Laboratories treated the prostate cancer cells with a combination of drugs including bicalutamide (an anti-androgen that opposes the action of androgen on the tumor), and the inhibitors 17AAG and vorinostat.
Professor Tilley said that growth of prostate cancer is initially dependent on hormones called androgens, which traditionally have been suppressed to stop tumor growth. However, despite an initial response, resistance to hormone deprivation often occurs and the tumor starts to grow again,
"Men undergoing hormone deprivation therapy can also experience significant side effects, including reduced libido, impotence, hot flushes, tiredness and sweating, gradual decrease in body hair, reduced bone and muscle strength and cognitive changes," he said.
The new treatment could effectively curb disease progression by killing prostate cancer cells.
These new drugs 17AAG and vorinostat can block key cancer survival pathways, but are not particularly effective in killing prostate cancer cells if given alone.
"We can now confirm that a very low level of bicalutamide is capable of inhibiting cancer cell proliferation by more than 10-fold when combined with either vorinostat or 17AAG, making our current treatments much more effective and causing fewer side effects," said Butler.
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More News on: Prostate Cancer, Cancer and Homeopathy, Check your prostate gland, Prostatitis Symptom Score Calculator, Trans-Urethral Resection of the Prostate, Prostate Cancer Facts, Cancer Facts, Cancer, Hematuria, Prostate Cancer: Treatment Options
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07/16/2009
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It reduces the size of tumour, & PSA levels .