A study has claimed that the more of a man's direct relatives, like brothers and fathers, are affected with prostate cancer, the higher is his personal risk for the disease.
Researchers of the department headed by Kari Hemminki at DKFZ have studied how high is an individual person's risk in familial prostate cancer.
AdvertisementThe largest ever such study included 26,651 prostate cancer patients, 5,623 of whom came from families in which the disease had been diagnosed before.
And the researchers calculated that men up to an age of 65 years with three affected brothers have a risk that is 23 times higher than that of the control group (men without affected family members).
Men aged between 65 and 74 years, whose father was or is the only one affected, have a risk that is increased by 1.8 times and, thus, the lowest risk elevation in the familial cancer group.
The DKFZ researchers recognized a general tendency that the personal risk is the higher, the younger affected relatives were at the time of diagnosis.
Elevated familial cancer risks are often doubted.
Critics argue that results tend to be distorted because relatives of affected persons are alarmed and have early detection exams more often than the rest of the population.
Thus, the argument runs, they are more frequently overdiagnosed, because even tumours are found that might never have caused any symptoms during their lifetime.
In order to refute this criticism, the researchers also investigated the prostate cancer mortality in relation to the number of affected family members.
They arrived at the same risk distribution as for newly diagnosed cases-the more direct relatives are affected, the higher is a person's risk of dying from prostate cancer.
Thus, the scientists have proved that the risk increase is real and not just due to more frequent early detection examinations.
"Our results provide a good guidance for doctors. If a man has several affected relatives who may even have been diagnosed at a young age, then his personal risk is substantially increased. In this case, a family doctor should urgently recommend having an early detection examination," said study head Kari Hemminki.