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Prostate Cancer Patients on Androgen Deprivation Therapy Have Increased Risk of Colorectal Cancer
Androgen deprivation therapy is a widely-prescribed treatment in men with prostate cancer, although its usage for low-risk disease remains controversial, given the adverse side effects, including osteoporosis, cardiovascular disease, diabetes and obesity; the last two are risk factors for colorectal cancer.
To determine whether prostate cancer patients taking androgen deprivation therapy are at an increased risk of colon cancer, Silke Gillessen, M.D., of the Cantonal Hospital in St. Gallen, Switzerland, and colleagues, did an observational study of men with prostate cancer identified through the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute. Specifically, they identified 107,859 men aged 67 years or older who were diagnosed with prostate cancer between 1993 and 2002, with follow-up through 2004. The men received the ADT either in the form of gonadotropin-releasing hormone (GnRH) agonists, or an orchiectomy.
The researchers found that after adjustment for confounding variables such as age and socio-economic status, there was a 30-40% relative increase in the rate of colorectal cancer among the men treated with ADT compared with those who were not. Furthermore, the longer the men took ADT, the greater their risk of developing colorectal cancer. However, further study would be needed to determine the risk with treatment over longer periods than could be observed in this study.
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More News on: Prostate Cancer, Cancer and Homeopathy, Check your prostate gland, Prostatitis Symptom Score Calculator, Trans-Urethral Resection of the Prostate, Colo-rectal cancer - Management, Colorectal Cancer, Reiki and Pranic Healing, Prostate Cancer Facts, Cancer Facts
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