Promising New Therapy for Relapsing Multiple Sclerosis

by Rajshri on  February 18, 2010 at 6:50 PM Research News
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A new study has revealed that patients with relapsing multiple sclerosis who combine standard treatment with doses of a humanized monoclonal antibody called daclizumab might develop fewer new or enlarged brain lesions than if they use the standard treatment alone.

Multiple sclerosis (MS) is a debilitating disease in which the body's immune system attacks the fatty substance that surrounds and protects the nerve fibers in the brain and spinal cord.

The resulting damage interferes with the transmission of nerve signals between the brain and spinal cord and other parts of the body, producing a variety of symptoms including problems with balance, coordination, vision, and even mental function.

Approximately 85 percent of multiple sclerosis patients are initially diagnosed with relapsing MS, in which clearly-defined attacks of worsening neurologic function are followed by partial or complete recovery periods during which no disease progression occurs.

"Previous research has shown that treatment with daclizumab reduced multiple sclerosis disease activity," says John W. Rose, professor of neurology at the University of Utah School of Medicine, Neurovirology Research Laboratory, Veterans Affairs Salt Lake City Health Care System and the University of Utah, an author on the study.

"Our work in the CHOICE trial shows that daclizumab significantly reduces MS lesion formation in people with active relapsing disease," he added.

Monoclonal antibodies are immune system proteins that preferentially bind to specific target cells, triggering the immune system to attack those cells.

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