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Promising Drug Therapy in Deadly Lung Cancer
The multicenter study is testing whether the drug crizotinib effectively slows, stops or reverses growth in advanced non-small cell lung cancer tumors by targeting a genetic mutation that causes uncontrolled tumor growth. Study participants all tested positive for a mutation in the anaplastic lymphoma kinase gene.
According to the findings, tumors disappeared or shrank in 57 percent of patients. Tumors ceased growing in another 33 percent. The response rate to the current standard of care for advanced non-small cell lung cancer is about 15 percent.
"For the majority of patients, the treatment right now is chemotherapy plus targeted therapy in those eligible," said Dr. Ignatius Ou. "In the future, with the advance of personalized medicine, we hope to be able to identify specific genetic change in the lung cancer and treat patients with specific inhibitors that can improve survival rates and quality of life."
The study includes data from 82 patients treated in Phase 1 of this study, sponsored by the pharmaceutical company Pfizer. The targeted genetic mutation is particularly prevalent among those who have never smoked. Study participants ranged in age from 25 to 78, with 76 percent of them nonsmokers.
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More News on: Drug Toxicity, Lung Cancer, Malignant Mesothelioma, Cancer and Homeopathy, Smoking Risk, Reiki and Pranic Healing, Signature Drug Toxicity, Cancer Facts, Asbestosis , Cancer
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