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Progress of Lupus can Be Stopped by Genetic Mutation
January 18, 2008 at 5:24 PM
Genetics & Stem Cells News
“The mutation reduced symptoms of the disease by interfering with the development and activation of T cells and other immune responses,” said Dwight Kono, an associate professor at The Scripps Research Institute. “These findings solidify the critical role of Coronin-1A in normal immune responses, and identify it as a potential therapeutic target for lupus.”
Two Sides of Lupus Genetics
Systemic lupus erythematosus is a serious autoimmune disease that affects approximately 1.5 million Americans. It is influenced by genetic, environmental, and hormonal factors, although genetic predisposition appears to be the single greatest contributor to its onset.
There has been considerable interest in defining the genetics of systemic lupus erythematosus in recent years, not only for gaining a better understanding of the fundamental causes of the disease but also for the development of potential therapies.
“We were searching for a lupus susceptibility gene,” Kono said. “After mapping and cloning the Coronin-1A gene, we discovered this spontaneous mutation in a single strain of mice-those that don’t get severe or systemic lupus-like disease. More than likely, the mutation had existed undetected in our mouse colony for years.
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