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Preoperative Chemo Response Indicates Survival For Pancreatic Cancer Patients
Pancreatic adenocarcinoma is rarely detected in early stages, making treatment difficult and survival statistics particularly grim.
In 1986, the Center conducted the first trial in pancreatic cancer of "multimodal" preoperative therapy (the use of more than one kind of treatment, such as chemotherapy and radiation, to kill tumour cells before surgery), and a phase I trial of gemcitabine in the 1990s established the safe dosage for the chemotherapy drug, now widely used in treating the disease.
In current study, led by Dr. Yun Shin Chun, the researchers wanted to know whether response to preoperative therapy predicts survival in pancreatic adenocarcinoma-the most common type of pancreatic cancer.
"For many cancers-breast, esophagus, stomach, and colorectal liver metastases-it has been shown that survival is much better in people who have a good pathologic response to preoperative therapy-meaning that many tumour cells are killed-than in people who do not have a good pathologic response. But this has not been established in pancreatic cancer; previous studies have shown conflicting results," said Chun.
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