Potential Reason Found Out for Early Pregnancy Loss

by Medindia Content Team on  September 21, 2007 at 8:25 PM Women Health News
RSS Email Print This Page Comment bookmark
Font : A-A+

Potential Reason Found Out for Early Pregnancy Loss
The National Institutes of Health, Bethesda, have found out that mice having reduced levels of Sphk2 (Sphk1-/-Sphk2+/- mice) and lack of protein known as Sphingosine kinase were found to be infertile. The discovery has provided a key reason for early pregnancy loss in humans.

Female mice lacking a protein known as sphingosine kinase 1 (Sphk1) and expressing reduced levels of Sphk2 (Sphk1-/-Sphk2+/- mice) were found to be infertile. Although embryos implanted into the womb, the womb failed to respond correctly to this — the structures that support the developing embryo before a functional placenta is established (the decidua) were defective.

In particular, there was increased death of decidual cells and breakage of decidual blood vessels, which led to hemorrhaging and early pregnancy loss. As Sphk1 and Sphk2 are involved in metabolizing a group of fats known as sphingolipids, the authors suggested that disturbances in sphingolipid metabolism might be a cause of early pregnancy loss in humans.

Source: Eurekalert
JAY/C

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Trimester of pregnancy Pregnancy and Exercise Home Pregnancy Test Pregnancy Psychological Changes In Pregnancy Drugs in Pregnancy and Lactation Breech Presentation and Delivery Air travel: To fly or not to fly Pregnancy and Antenatal Care AIDS and Pregnancy 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive