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Potential Drug Targets for Sepsis Identified
By disrupting this pathway, the scientists could save mice from death due to sepsis.
Although researchers led by Scripps Research Professor Wolfram Ruf and his postdoctoral fellow Frank Niessen, don’t guarantee that this preclinical success will translate into human therapies, they believe that their experiments may perk up the diagnosis of heterogeneous sepsis syndromes and yield potent drugs for treating people who suffer from sepsis.
“We have identified a key connection of signaling pathways in the cascade of events leading to sepsis. This defines a crucial point where the immune system spirals out of control to cause severe sepsis and where there is an opportunity for therapeutic intervention,” Nature quoted the authors, as saying.
The disease sepsis is quite severe, fast moving, dramatic, and often fatal. It is caused due to a violent bacterial infection that enters the bloodstream. Tythe invasion by these bacteria leads to the production of endotoxins and other toxic chemicals initiating a widespread inflammatory response of the innate immune system.
Scientists have for long being trying many therapeutic approaches for the treatment of sepsis. The sole option for many years was to give powerful, broad-spectrum antibiotics for controlling the bacterial infection. But usually, it was too late by the time these were administered.
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