Pig Model Could Help to Find Treatment for Cystic Fibrosis

by Sreeraman on  September 27, 2008 at 11:58 AM Research News
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In a breakthrough study, a University of Missouri researcher is producing pigs born with cystic fibrosis (CF) that mimic the exact symptoms of human CF, and may help in further studying the deadly lung disease. Cystic Fibrosis continues to be a lethal disease for humans despite the identification of the problematic gene two decades ago. Many humans born with CF - the most common genetic disease in Caucasians - often die because of a lung disease developed later.

Till date, scientists have been not been able to develop an animal model that develops the fatal lung disease.

But now, the researchers are hopeful that these pigs will continue to mimic the human symptoms so the fatal lung disease can be studied and ultimately treated. Right now, if you want to do experiments to find treatments or therapies for the lung disease that is fatal for people with CF, you would have to experiment on kids that have CF," said Randy Prather, distinguished professor of reproductive biotechnology in the MU College of Agriculture, Food and Natural Resources.

He added: "When the genetic mutation is introduced into mice, they do not display the symptoms of CF. That's why these new swine models are so important. We have been able to get them through the initial stages of the disease, which they display just like humans, and now we are just waiting for them to grow and potentially develop the lung disease so we can start experimenting in ways that have never been possible."

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