Anticoagulation service directed by a pharmacist ensures proper dosage for patients with heparin-induced thrombocytopenia (HIT), a common but life-threatening thromboembolic disorder.
Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count), due to the administration of various forms of heparin, an anticoagulant. HIT predisposes to thrombosis, the abnormal formation of blood clots inside a blood vessel, and when thrombosis is identified the condition is called heparin-induced thrombocytopenia and thrombosis (HITT). HIT is caused by the formation of abnormal antibodies that activate platelets.
Researchers found that patients treated by the anticoagulation service had a favorable response to alternative anticoagulant drugs three times faster and were 32 percent more likely to receive proper dosage than patients who were treated with the same drugs by the patient's primary medical team.
This is the first time researchers evaluated the impact of the anticoagulation service on the efficiency and safety of using a different class of anticoagulant drugs called direct thrombin inhibitors for treating patients with HIT, in which a patient's platelet count drops after they receive the anticoagulant drug heparin.
The study is to be published online Tuesday at www.theannals.com in the February issue of The Annals of Pharmacotherapy.
"Based on our findings, we believe this type of service is a valuable strategy for improving the quality of care of patients with HIT," says James Kalus, PharmD, senior clinical pharmacy manager at Henry Ford and senior author of the study.
It is estimated that up to 3 percent of patients exposed to various forms of heparin may develop HIT, which is commonly treated in hospitalized patients. If a decrease in a patient's platelet count is not treated quickly and efficiently, serious blood clots can develop.
Henry Ford sought to evaluate whether a pharmacist-directed anticoagulation service could impact the care or outcomes of 193 HIT patients who were treated using direct thrombin inhibitors lepirudin or argatroban between 2005 and 2009. Ninety-eight patients were managed by the anticoagulation service and 95 patients were managed by the primary medical team.
Dr. Kalus says the study's findings "represent real improvements in quality of care."
"The pharmacist-directed anticoagulation service is a viable approach to standardize the use of direct thrombin inhibitors for improving both the efficiency and safety of these complicated medications in an inpatient setting," he says.
The study was funded by Henry Ford Hospital.