People With Retinal Degeneration may Benefit from Human Embryonic Stem Cell Therapy

by Rajashri on  October 4, 2009 at 11:01 AM Genetics & Stem Cells News   - G J E 4
 People  With Retinal Degeneration may Benefit from Human  Embryonic  Stem  Cell Therapy
Cells derived from human embryonic stem cells (hESCs) have been used to reverse retinal degeneration in an animal model. This news offers new hope that a cure for the devastating eye disease may be available in the near future.

In their laboratory, Dr. Benjamin Reubinoff, Dr. Eyal Banin, and their colleagues from Hadassah-Hebrew University Medical Center in Jerusalem developed conditions to guide hESCs to differentiate into functional cells that resembled the retinal pigment epithelium (RPE).

The researchers described RPE as a layer of pigmented cells sandwiched between the visual retinal cells, called photoreceptors, and the nourishing blood vessels at the back of the eye.

They found that nicotinamide (vitamin B3, NIC) and Activin A, an important growth factor, promoted differentiation of hESCs towards an RPE fate.

According to them, the hESC-derived cells exhibited the defining characteristics associated with RPE.

When the researchers transplanted them into an animal model of retinal degeneration, the cells rescued the retina.

"Our findings are an important step towards the potential future use of hESCs to replenish RPE in blinding diseases," concludes Dr. Banin.

A research article describing the study has been published in the journal Cell Stem Cell.

Source: ANI

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions
Standing singly, away from all the controversy, some of the scientific community is giving rise to the World's very first patented organic stem cell enhancer.
raymumme Friday, October 9, 2009

You May Also Like

View All