Most Popular News on Medindia

P
M

Parkinson's Related to Cause of Severe Sleep Disorder

by Tanya Thomas on  June 20, 2011 at 11:35 PM Research News   - G J E 4
Researchers at the University of Toronto have identified a potential cause for a severe sleep disorder that could also have implications for Parkinson's disease and other neurodegenerative diseases.
 Parkinson's Related to Cause of Severe Sleep Disorder

"Our research is the first to establish a potential genetic link to human REM sleep behaviour disorder (RBD). That's important because between 60 and 80 per cent of people diagnosed with human RBD develop Parkinson's disease or other neurodegenerative disorders later in life," said Dr. John Peever, lead author of the study.

Peever's team focused on investigating a genetic cause of RBD because the underlying cause of this disorder is unknown. There is evidence indicating that reduced brain inhibition could cause RBD, so Peever's team genetically reduced brain inhibition in mice and then recorded their sleep and muscle activity.

"We found that mice with reduced brain inhibition acted just like human RBD patients and they moved violently during REM sleep," said Peever.

"This link strongly suggests that patients with RBD may also have impaired brain inhibition."

Peever's research underscores the importance of identifying a cause of RBD as 60 - 80 per cent of RBD sufferers subsequently develop Parkinson's.

"Treating RBD could have direct implications for understanding and perhaps treating Parkinson's disease," he added.

The study was recently published in The Journal of Neuroscience.

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

Ask an Expert

C
If you have a question about health related issues, you can now post it in our Ask An Expert section on our community website Medwonders.com and get answers from our panel of experts.
X

Ask an Expert

Ask an Expert+
s
Men Hire Cleaners More Often Than Women Do - So W...
 Men Hire Cleaners More Often Than Women Do - So Which Sex is Really Cleaner?
S  Noninvasive Brain Implant Could Someday Translate Thoughts into Movement
Noninvasive Brain Implant Could Someday Translate...