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Parkinson's Protection by Molecules, Identified
During the study, the team came across four related small molecules that prevented the development of several cellular traits associated with Parkinson's disease, including the accumulation of alpha-synuclein deposits in the cell, improper protein trafficking from one organelle to another, and damage inflicted on the cells' engines, the mitochondria.
"In this research, we used yeast as a Parkinson's disease model system to identify the compounds that really work in two higher order model systems of Parkinson's," said Julie Su, a first co-author on the paper describing the research and a former postdoctoral researcher in Whitehead Member Susan Lindquist's lab.
The yeast was modified to produce too much of the alpha-synuclein protein in its cells. The resulting cells manifest adverse effects similar to those experienced in brain cells from Parkinson's patients.
Using this yeast strain, the Lindquist team screened 115,000 small compounds to see which ones alleviate the Parkinson's-like traits. During a screen, a compound is added to a small amount of yeast
Four compounds were found to restore the alpha-synuclein yeast cells' growth to 50pc of normal yeast cells. Yeast cells that were not treated with the compounds died.
The researchers also identified two commercially available compounds with similar chemical structures and used those in further tests.
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