Medindia

X

Parkinson's Gene Linked to Immune System

by Rathi Manohar on  August 31, 2010 at 7:23 PM Mental Health News   - G J E 4
Parkinson's disease has a genetic link that is related to the immune system, and scientists feel that this discovery would help in new drug development.
 Parkinson's Gene Linked to Immune System
Parkinson's Gene Linked to Immune System
Advertisement

Johns Hopkins researchers from the Center for Inherited Disease Research confirmed that a gene in the human leukocyte antigen (HLA) region was strongly linked with Parkinson's disease; this region contains a large number of genes related to immune system function.

Advertisement
This genetic finding demonstrates that inflammation isn't simply a result of having the disease, but somehow is involved as a player in its origin, reports Nature.

"This is an exciting finding from a genome-wide association study (GWAS) which is completely hypothesis-independent and bias-free, based solely on looking at the whole genome and finding out what genes might be related to Parkinson's," said Kimberly Doheny.

"This finding anchors the idea of immune system involvement in genetics and brings it out to the forefront in terms of where research should be directed," said Haydeh Payami.

Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are protective against Parkinson's disease, according to the study. However, not everyone benefits from them to the same degree.

The amount of risk reduction conferred by NSAIDs may vary widely depending on genetic differences, say the researchers. Investigating the connection between Parkinson's disease and inflammation, especially in the context of the variable genetic make-ups of individuals, likely would lead to better, more selective medicines for treatment.

The new data is published in Nature Genetics.

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All