By analysing blood samples, we found that those patients from the higher dose fish oil group had lower levels of inflammatory mediators than those in the lower dose fish oil group, with the study demonstrating that suppression of COX activity by paracetamol is enhanced by fish oil ingestion, she says.
The findings provide encouragement for clinical trials to evaluate the benefits of combined therapy with long-term fish oil and paracetamol by comparison with traditional anti-inflammatory medicines in osteoarthritis. If the effectiveness of this inexpensive combination proves comparable to that of NSAIDs, its improved safety relative to long-term NSAID therapy will be especially advantageous.
Source-Medindia