Optical techniques developed by researchers, has detected the presence of pancreatic cancer through analysis of neighboring tissue in the duodenum and part of the small intestine neighboring the pancreas.
Vadim Backman, professor of biomedical engineering at the McCormick School of Engineering and Applied Science at Northwestern, has revealed that the new technology has shown some promise in clinical trial results.
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Backman and graduate student Vladimir Turzhitsky have revealed that their technology uses novel light-scattering techniques to analyze extremely subtle changes in the cells of the duodenum. The cells are obtained through a minimally invasive endoscopy, they say.
The researchers observed during the study that cells that appear normal using traditional microscopy techniques do show signs of abnormality when examined using the Northwestern technique, which provides cell analysis on the much smaller nanoscale.
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The researchers said that the technique accurately discriminated with 95 percent sensitivity between healthy patients, and those with differing stages of the disease. According to them, only five percent of patients were found to have been diagnosed with false negatives after testing.
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Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
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The larger number of patients in the more recent study allowed researchers to calculate the "area under the receiver operator characteristic" (AUROC), which is an analysis of the accuracy of the test in distinguishing healthy samples from diseased samples.
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The analysis showed an 85 percent AUROC for the Northwestern method.
In their study report, the researchers write that their study also showed promising results in detecting mucinous cyst lesions, which are a precursor to cancer.
They say that their approach may pave the way for a method for early diagnosis, if further clinical trials confirm their results.
"Typically, by the time a patient is diagnosed with pancreatic cancer, it is too late for the most successful treatments. Our hope is that this technology will provide a better method for early diagnosis of the disease, which could greatly improve the survival rate," says Backman.
Source-ANI
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