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Oxygen Overdose Could Slow Wrinkle Formation: Study

by VR Sreeraman on June 30, 2010 at 5:20 PM Anti-Aging News

An overdose of oxygen could help reduce wrinkle formation by lessening tissue damage due to UVB rays, according to a Japanese study.

Oxygen Overdose Could Slow Wrinkle Formation: Study

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In the study, mice that were placed in an oxygen chamber after exposure to UVB radiation developed fewer wrinkles and showed fewer signs of tissue damage than those that were exposed to UVB radiation alone.

The readily visible hallmarks of skin damage are wrinkles and a thickening in the outer layer of skin, the epidermis.

When skin is repeatedly exposed to UVB radiation, new blood vessels form from existing blood vessels in the skin in a process called cutaneous angiogenesis.

Several transcription factors-proteins that bind to specific DNA sequences-play a role in angiogenesis, including hypoxia inducible factor (HIF-1) and its subunit HIF-1 a and vascular endothelial growth factor (VEGF).

In the study, the researchers assigned 24 hairless mice into three groups-the control group, the UVB group, and the UVB+HO group.

Both the UVB and the UVB+HO groups were exposed to UVB radiation by a special fluorescent lamp three times per week for five weeks, but the UVB+HO mice were placed in an oxygen chamber for two hours after each irradiation.

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