A new mice study has revealed that over-expression of the protein km23-1 was responsible for causing the death of ovarian cancer cells.
Pulipati et al conducted this animal study after assessing the results of a previous study, which showed that a subunit of the motor protein dynein called km23-1 was defective in ovarian cancer patients. This protein is the one that transports checkpoint proteins along the microtubules during mitosis.
In this particular study, researchers induced over-expression of km23-1 in human ovarian cancer cells transplanted in mice. The researchers reported that the size of the tumors in mice with this over-expressed protein was significantly reduced compared to mice, which did not have over-expression of this protein.
The study is explained in detail in the latest issue of the International Journal of Cancer.