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Osteoporosis Drug Can Jumpstart Elderly Body's Natural Healing Process In Bones
"When they would come back for their follow-up visits three months later, it was amazing to see not just the significant healing in their fractures, but to realize they were pain-free, a new and welcome experience for many of these patients," she added.
When a fracture occurs, a bone becomes unstable and can move back and forth creating a painful phenomenon known as micromotion. As the bone begins healing it must progress through specific, well-defined stages.
First, osteoclasts, cells that can break down bone, clean up any fragments or debris produced during the break. Next, a layer of cartilage, called a callus, forms around the fracture that ultimately calcifies, preventing the bony ends from moving, providing relief from the significant pain brought on by micromotion.
Only after the callus is calcified do the bone forming cells, osteoblasts, begin their work. They replace the cartilage with true bone, and eventually reform the fracture to match the shape and structure of the bone into what it was before the break.
According to Puzas, teriparatide significantly speeds up fracture healing by changing the behaviors and number of the cartilage and the bone stem cells involved in the process.
"Teriparatide dramatically stimulates the bone's stem cells into action. As a result, the callus forms quicker and stronger," said Puzas.
Source-ANI
ARU
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