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Oral Drug Protects Healthy Tissue From Radiation In Non-Small Lung Cancer
The findings of researchers with the University of Pittsburgh Cancer Institute (UPCI) support further clinical testing of the agent called manganese superoxide dismutase (MnSOD) plasmid liposome. The idea was to determine whether alongside chemotherapy and radiation, the new agent can prevent damage to normal cells that is the typical cause of side effects in cancer treatment, said senior investigator Joel S. Greenberger, M.D., professor and chair, Department of Radiation Oncology, Pitt School of Medicine, and co-director of the lung and esophageal cancer program at UPCI.
If we can sufficiently protect tissues that are normal, we should be able to deliver our cancer treatments more effectively and perhaps even at higher doses, he explained. Our aim is to improve the quality of life of patients by minimizing side effects while providing the best treatment for their cancers.
For the safety study, 10 patients with inoperable stage III non-small cell lung cancer took oral doses of MnSOD plasmid liposome twice weekly for a total of 14 doses during seven weeks of conventional chemotherapy and radiation treatment. The agent, which boosts levels of an antioxidant the body makes naturally, is made of fat droplets containing the gene that produces MnSOD.
When swallowed, it is absorbed by cells in the esophagus, which is a common site for severe side effects during radiation treatment for lung cancer.
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More News on: Drug Toxicity, Lung Cancer, Malignant Mesothelioma, Radiotherapy, X-Ray, Cancer and Homeopathy, Smoking Risk, Signature Drug Toxicity, Cancer Facts, Asbestosis
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