According to modelling research presented by Beate Sander, University of Toronto, Canada, a stockpile of Tamiflu sufficient to cover 65% of a country's population could cut deaths by approximately half.Treatment with the oral antiviral Tamiflu (oseltamivir) and prophylaxis for people exposed to infected patients could be one of the most cost-effective strategies for reducing illness and death during an influenza pandemic.
The reality is that country stockpiles of Tamiflu are limited and are targeted at treatment only rather than treatment and prevention.2 However, some governments are now planning for sufficient antiviral stockpiles that will allow them to provide Tamiflu preventatively to close contacts of infected individuals.
The disease modelling research analysed for the first time the cost-effectiveness of strategies to reduce the spread of pandemic influenza using Tamiflu prophylactically. It was predicted that this preventative approach is likely to be more cost-effective than treating symptomatic patients alone and may be an effective and cost-saving measure for reducing the impact of pandemic influenza.
This research is supported by an earlier analysis that indicates that a prevention strategy using Tamiflu may help contain a pandemic outbreak.
The study also predicts that if the stockpile is increased so that there is an unlimited supply of Tamiflu for treating symptomatic patients and for preventing infection in people exposed to these patients (household contacts and school/work contacts), illness attack rates and deaths could potentially be reduced by more than half when compared to no intervention.
This equates to a cost saving of 70,000 dollar per 1,000 population which would save 21 billion dollar in the US alone versus no intervention. Adding other strategies such as school closures further reduces the attack and death rate and provides a health benefit at a reasonable cost. The research also showed that pre-pandemic vaccination programmes would play an important role but their effectiveness would be dependent upon how well the vaccine was matched to the virus.
"The World Health Organisation provides a strong recommendation for the use of Tamiflu for the prevention of avian flu in people who have been in contact with someone who is known, or suspected of being infected with the virus," commented Professor Ira Longini, Professor of Biostatistics and Mathematics at the University of Washington, Seattle, USA.
"This research suggests that a similar approach may also be an effective strategy in the event of an actual pandemic outbreak, especially as it is unlikely that a vaccine fully matched to the strain will be available in the initial wave of a pandemic."