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Obesity Can Boost Negative Effects of Asthma
What's more, it may also mask its severity in standard tests, according to researchers in New Zealand.
The researchers who studied lung function in asthmatic women with a range of body mass indexes (BMIs) found significant differences in the changes in respiratory function that occur with asthmatic bronchoconstriction in relation to obesity.
This is the first prospective study to reveal a significant comparative difference in how the airways and lungs respond to a simulated asthma attack in obese and non-obese individuals.
It establishes a direct link between obesity and the development of a phenomenon known as "dynamic hyperinflation"-when air breathed into the lungs cannot be exhaled.
This often occurs with acute asthma, but is more frequent in obese individuals.
"We have demonstrated significant differences in the changes in respiratory function that occur with asthmatic bronchoconstriction in relation to obesity," said principal investigator, D. Robin Taylor, M.D., of the University of Otago in New Zealand.
In the study, the researchers recruited 30 asthmatic women and divided them into three groups by BMI: normal weight, overweight and obese.
Each woman breathed nebulized methacholine to artificially induce an asthma-like attack, and was then assessed for changes in lung function on several measures, including how much air remained in her lungs after exhalation (functional residual capacity, or FRC) and how much air she could breathe in on her next breath (inspiratory capacity, or IC).
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