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Obese Colon Cancer Patients Have Poor Survival Rate, Finds Study
The study has been reported in Clinical Cancer Research, a journal of the American Association for Cancer Research.
"Obesity has long been established as a risk factor for cancer, but our study in colon cancer patients shows that obesity predicts a poorer prognosis after the cancer is surgically removed," said Frank A. Sinicrope, M.D., professor of medicine and oncology at the Mayo Clinic in Rochester.
In the study, Sinicrope and colleagues evaluated 4,381 patients with stage II or stage III colon cancer who had received adjuvant chemotherapy in clinical trials. Of these patients, 20 percent were obese.
Obesity was significantly linked with poorer overall survival and was independent of other variables analyzed. The prognostic impact was stronger in men than in women, and men in the highest body mass index category for obesity had a 35 percent increased risk of death compared to normal weight patients. The weaker effect in women is consistent with studies that have shown a lower risk of developing colon cancer in obese women compared to obese men.
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