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Obese Children Metabolize Drugs Differently Compared to Normal Kids
As part of the study, researchers from the University of Minnesota College of Pharmacy evaluated drug metabolism in sixteen healthy weight children and nine obese children.
"We have known for years that drugs metabolize differently in obese adults as compared to healthy weight adults. But, there has been very little, if any, information available that specifically addresses the consequences of obesity on drug metabolism in children. Without this information, our ability to identify optimal drug dosing in children often relies on trial and error approaches," said L'Aurelle Johnson in the Department of Experimental and Clinical Pharmacy.
In the study, Johnson and co-author Manoj Chiney examined drug metabolizing enzyme activity in healthy weight and obese children, age 6 to 10 years old.
Specifically, they looked at how the children metabolized caffeine and dextromethorphan, a key ingredient in the cough suppressant Robitussin DM.
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