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Now, Nontoxic Nanoparticle That Delivers and Tracks Therapeutic Drugs
Mark Kester, professor of pharmacology, and Jong Yun, associate professor of pharmacology, both at Penn State College of Medicine, optimized ceramide, a chemotherapeutic molecule that initiates cell death in cancer cells and known for its ability to slow growth in healthy cells, for both cancer and vascular disease.
It was found that by using human vascular smooth muscle cells in vitro, ceramide encapsulated in calcium phosphate nanoparticles reduced growth of muscle cells by up to 80 percent at a dose 25 times lower than ceramide administered freely, without damaging the cells.
Lead author Thomas Morgan, graduate student in chemistry said that the nanoparticles have several benefits that other drug delivery systems do not.
Unlike quantum dots, which are composed of toxic metals, calcium phosphate is a safe, naturally occurring mineral that already is present in substantial amounts in the bloodstream.
"What distinguishes our method are smaller particles (for uptake into cells), no agglomeration (particles are dispersed evenly in solution), and that we put drugs or dyes inside the particle where they are protected, rather than on the surface. For reasons we don't yet understand, fluorescent dyes encapsulated within our nanoparticles are four times brighter than free dyes," said Morgan.
The study is published in a recent online issue of Nano Letters.
Source-ANI
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