Medindia

X

Now, T-Cells May BE Made HIV-Resistant With New Genetic Strategy

by Tanya Thomas on  January 29, 2011 at 11:34 AM AIDS/HIV News   - G J E 4
Scientists have come up with an innovative genetic strategy for rendering T-cells resistant to HIV infection without affecting their normal growth and activity.
 Now, T-Cells May BE Made HIV-Resistant With New Genetic Strategy
Now, T-Cells May BE Made HIV-Resistant With New Genetic Strategy
Advertisement

A team of researchers from Japan, Korea, and the U.S. developed an anti-HIV gene therapy method in which a bacterial gene called mazF is transferred into CD4+ T-cells. The MazF protein is an enzyme (an mRNA interferase) that destroys gene transcripts, preventing protein synthesis.

Advertisement
The design of this mazF gene therapy vector ensures that synthesis of the MazF protein is triggered by HIV infection. When HIV infects treated T lymphocytes, MazF is induced, blocking HIV replication and, essentially, making the T-cells HIV resistant.

"The potential of using vectors to express genes within a cell to block viral infection was first considered by David Baltimore in a strategy called 'intracellular immunization.' This study illustrates a unique way in which intracellular immunization can be achieved," said James M. Wilson, Editor-in-Chief, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.

The finding has been published in Human Gene Therapy.

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions
HIV is not actually a death sentence. It is a disease that can be managed and be controlled by the individual who acquired it allowing him to live a long normal and productive life like anyone else. Pozmingle.com the largest dating site for HIV singles claim that they have 200,000 HIV members, Most of them are here to find understanding, support and love. It is really a good thing that encourage each other, Leading a healthy life.
juliarix Saturday, January 29, 2011

You May Also Like

Advertisement
View All