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Novel Therapies To Treat Breast And Lymph Cancer Developed

by Aruna on June 01, 2009 at 2:11 PM Cancer News

Research unveiled at a major cancer conference says, new therapies have developed following groundbreaking clinical trials appear to effectively target breast cancer and non-Hodgkin's lymphoma.

Novel Therapies To Treat Breast And Lymph Cancer Developed

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The first therapy targeting the capacity of cancer cells to repair themselves shows promise in treating breast cancer, according to results of two small clinical trials.

The new agent, especially adept at targeting cancers that are most difficult to cure, neutralizes an enzyme called PARP (poly-ADP-ribose-polymerase) and prevents it from playing its usual role in repairing the DNA of damaged cells.

Like healthy cells, cancerous cells employ PARP to regenerate themselves after they have been damaged by chemo-therapy treatments.

The studies examined whether breast cancers are more susceptible to chemotherapy when the PARP enzymes have been neutralized.

The first clinical trial was conducted with 116 women suffering from so-called triple negative breast cancer.

These involve fast-spreading tumors that account for 15 percent of the 170,000 annual cases worldwide of breast cancer.

Some of the cases were treated with chemotherapy and a PARP inhibitor called BSI-201 made by the firm BiPar Sciences, a US affiliate of the French-owned laboratory Sanofi-Aventis.

The rest of the group was treated only with chemotherapy.

After six months, about 62 percent of the patients treated with BSI-201 combined with chemotherapy showed a comparative clinical improvement of 21 percent over the control group, said Joyce O'Shaughnessy, of the Baylor-Charles Sammons cancer center in Dallas, Texas.

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