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Novel Material Developed To Fight Arterial Disease
The condition is considered a red flag for vascular disease, heart attack and stroke, and its progression can result in the loss of limbs or death. While there are current treatments for PAD, including balloon angioplasty, stenting and bypass surgery, devices used in the latter two can frequently cause thrombosis, in which clots form inside blood vessels, obstructing blood flow and leading to serious complications.
The researchers are working on developing a PAD treatment device that can prevent thrombosis in small-diameter blood vessels.
They focused on stents that incorporate a material known as Nitinol, a superelastic nickel and titanium alloy that has the ability to be deformed and to recover its original shape upon heating.
"Nitinol, discovered back in the 1960s, is a shape-memory material. They thought it was going to revolutionize the engineering field. It wasn't until 1985 that people began to think this material would probably be great to use in a stent," said Greg Carman, a professor of mechanical and aerospace engineering and lead investigator for the multidisciplinary research team.
"The reason they liked it for a stent is because you could bend the material a very large distance and it would return back to its original shape.
"Other metals, such as surgical steel, do not allow such a large shape recovery and, as such, cannot be used in many stenting devices," Carman added.
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