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Novel Drugs To Combat Diseases Of Ageing Including Diabetes Type 2
November 30, 2007 at 4:02 PM
Drug News
Sirtris Pharmaceuticals focused on discovering and developing small molecule drugs to treat diseases of aging.
Sirtris scientists and Sirtris co-founder, Prof. David Sinclair from Harvard Medical School, had earlier found that resveratrol, a SIRT1 activator found in red wine, could reduce the impact of a high fat diet, increase stamina two fold and significantly extend lifespan.
It was estimated that a person would need to drink 1000 bottles of red wine to obtain an equivalent dose of resveratrol.
Christoph Westphal, Chief Executive Officer and Vice Chair of Sirtris Pharmaceuticals said that the new drug has considerable potential to treat diseases of aging such as Type 2 Diabetes.
"The new drug candidates represent a significant milestone because they are the first molecules that have been designed to act on genes that control the aging process,” Westphal said
"The breakthrough in potency we have achieved with the novel chemical entities (NCEs) means that we can obtain the health benefits of resveratrol with a considerably lower dose, " he added.
The World Health Organization (WHO) indicates that Type 2 Diabetes (formerly called adult-onset diabetes) results from the body’s ineffective use of insulin.
It accounts for 90percent of diabetes around the world, and is largely the result of excess body weight and physical inactivity.
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More News on: Diabetic Retinopathy, Drug Toxicity, Diabetes, Diabetic Diet, Otitis Media, Diabetes - Essentials, Diabetes - Self-Monitoring of Blood Glucose (SMBG), Anti-ageing and Benefits of Red Wine, Insulin Delivery Devices, Life Span or Death Clock
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11/30/2007
According to Wikipedia, Consumer Lab, an independent dietary
supplement and over the counter products evaluation organization,
published a report on 13 November 2007 on the popular resveratrol
supplements. The organization reported that there exists a wide range
in quality, dose, and price among the 13 resveratrol products
evaluated. The actual amount of resveratrol contained in the
different brands range from 2.2mg for Revatrol, which claimed to have
400mg of "Red Wine Grape Complex", to 500mg for Biotivia Transmax,
which is consistent with the amount claimed on the product's label.
Prices per 100mg of resveratrol ranged from less than $.30 for
products made by Biotivia, Jarrow, and Country life, to a high of
$45.27 for the Revatrol brand. None of the products tested were found
to have significant levels of heavy metals or other contaminants.
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