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Novel Drug Olaparib May Help Treat Women With Genetic Breast Cancer

Category: Women Health News RSS
Tuesday, June 02, 2009 at 10:21:13 AM
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Olaparib, a new drug, may help thousands of women suffering from genetic breast cancer, if results of the first tests on patients are to be believed.

The researchers behind the study tested the drug on 54 women with advanced genetic breast cancer, and found that the drug olaparib could stop the growth of tumors and shrink them in more than 40 per cent of cases.


In fact, one patient's tumor disappeared completely after treatment with the drug.

A large number of cases of breast cancer are caused by defects on the BRCA-1 and BRCA-2 genes, which put women at much higher risk of developing aggressive cancers of the breast or ovaries.

And, usually, women who test positive for the mutations have their breasts removed as a precaution, because they have an 80 per cent risk of developing breast cancer in their lifetime.

Olaparib, made by AstraZeneca, is the first of a new class of drugs specifically designed to treat BRCA-related cancers to be tested on patients.

Scientists have said that if further tests prove to be successful, they could be used at an early stage to treat or prevent disease occurring within affected families.

Andrew Tutt, director of the Breakthrough Breast Cancer Research Unit at King's College London, who led the trial, said that the results for olaparib were "very promising".

"We are hopeful that olaparib could provide a targeted treatment for women with BRCA-related breast cancer. Some women also develop breast cancer before they know they are carrying the gene, or see it recur if they have been diagnosed previously," Times Online quoted him as saying.
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LittleBear

6/18/2009

Great news. I'd like to know if women with family patterns of breast cancer but negative results for BRCA (that's c.50% of all genetically caused breast cancers) qualify for this drug.
Little Bear
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