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Novel Approach can Strengthen Immune System Against Childhood Cancer
"This is a way to convert a naturally occurring problem into a benefit in treating cancer," Nature Medicine quoted Dr. Malcolm Brenner, director of the Center for Cell and Gene Therapy at BCM, TCH and The Methodist Hospital, and professor of pediatrics and medicine at BCM, as saying.
He revealed that his team had used the novel approach in 11 patients with recurring neuroblastoma.
"For the first time, we started to see tumour responses. We have one complete remission and others who have had stable disease for more than a year," he added.
He revealed that the patients responded after only the one infusion of cells because they last a long time in the body and their numbers can increase.
Scientists previously failed to effectively use T-lymphocytes with an artificial receptor directed to tumour cells because they disappeared from the body too quickly to have an anti-cancer effect.
However, cytotoxic T cells that already have a natural receptor for the Epstein-Barr virus are continually activated by the presence of the virus, which is never eliminated from the body.
Brenner revealed that his team added to such T-lymphocytes a particular receptor for a protein called diasialoganglioside GD2, which is found in human neuroblastoma cells.
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