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No Chronic Fatigue Syndrome-XMRV Virus Link
"Our research was carried out under rigorous conditions - we looked at samples from well-studied patients, and we used very sensitive testing methods to look for the virus. If it had been there, we would have found it. The lab in which we carried out the analysis had never housed any of the murine (mouse/rat) leukaemia viruses related to XMRV, and we took great care to ensure there was no contamination. We are confident that our results show there is no link between XMRV and Chronic Fatigue Syndrome, at least in the UK," Professor Myra McClure, from Imperial College London, one of the authors of the new study, said.
The new UK research has been published in PLoS ONE.
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Gertrude(Guest)
01/17/2010
01/09/2010
One of the co-authors of this study, Simon Wessely, has a vested interest in the outcome of such virus studies. Simon has staked his entire academic career on the idea that neurological diseases like chronic fatigue syndrome are caused by purely psychological factors. Therefore Simon Wessely would be the last person you would want in a study like this: if he finds the virus in CFS patients, he shoots himself in the foot, and his career may never recover. So I wonder just how hard he looked for this XMRV virus. THEY ARE NOT STUDYING CFC PATIENTS Simon Wessely and company often use a different set of criteria to select the patients for their "CFS" studies (such as the Oxford Criteria). These selection criteria are set up so as to include lots of people that are just depressed, and do not have CFS at all. As a consequence, it is not surprising many studies, based on the Oxford Criteria or similar, find that patients do not have XMRV, or can be cured by antidepressants: they studied the wrong people. In other words, when Simon Wessely says "CFS", he actually is talking about "depression". Wessely loves to play language games, and frequently bends the definition of terms. You would be surprised how easily this fools people. The original XMRV research at the Whittemore Peterson Institute used the Canadian Consensus definition of CFS/ME. The advantage of these inclusion criteria is that they actually do select CFS patients. The odd thing is, the authors declared in this study that they have no competing interests: not true! It is very much in the interest of Simon Wessely to not find this XMRV virus. 01/11/2010
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I am not saying whether McClure’s study has been gamed or not but in my books some things she is quoted as saying in the media destroy her credibility.
She made a big deal out of emphasizing that the laboratory their samples were tested in have never housed any of the murine leukemia viruses and that they were certain their samples were not contaminated.
She had no reason to defend her study results for contamination because they found nothing. The only possible reason for her to say this was to imply that the WPI study was a result of contamination.
She must know that if this were the case then the approx. 200 healthy controls WPI tested would have has similar numbers of positive results to the 100 CFS/ME patients but instead the results were markedly different. 67% versus 3.7% of controls positive for XMRV. Just as well they did a lot of controls because this bolsters their results. I watched a video of presentations at the CFSAC conference where retrovirologist of 40 years Dr John Coffin said the possibility that these results were caused by contamination were very very remote.
Why does Dr McClure make deliberately misleading statements, which are completely unnecessary. She doesn’t even need to mention contamination as she found nothing. No matter what she says she was implying that the WPI study was contaminated and she must know its unlikely.
I don't know which study is right but I don't trust McClure or Wesselly. Why did they need to do a study before everyone else then make misleading statements. Its usually impossible to get funding for any research for ME but they got their funding really quick and made sure they got the jump on any further studies to come. I am suspicious.