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No BRCA Mutations Means High Risk for Breast Cancer Recurrence
The finding also raises questions about the use of sentinel node biopsy with prophylactic mastectomies in high-risk women.
The increased risk of developing breast cancer is already understood for women with the disease who test positive for a BRCA1 or 2 mutation.
Many of these women opt to have their breast surgically removed (prophylactic mastectomy) to cut their risk of developing breast cancer or developing a second breast cancer. The role of sentinel node biopsy remains controversial in this group.
"We know more about counselling women regarding prophylactic mastectomy if they have a BRCA mutation," said lead author Shawna C. Willey, MD, FACS, a member of the Breast Cancer Program at the Lombardi Comprehensive Cancer Center and director of the Betty Lou Ourisman Breast Health Center at Georgetown University Hospital.
"In high-risk women who have cancer but dont have a known mutation, we generally advise that the risk of developing a second cancer in the same or opposite breast is lower than it is for women who test positive for a mutation. This latest analysis has us re-thinking our approach," Willey added.
The study recruited women in a familial cancer registry at Lombardi who were enrolled between 1998 and 2007. The registry participants had at least a 10 percent probability of carrying a BRCA1/2 mutation based on personal or family history of cancer.
The cohort for the study involved 119 women. 74 women had a BRCA mutation (group 1) and 45 did not test positive for the mutation (group 2).
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More News on: Women and Cancer, Breast Biopsy, Pagets disease of the breast, Mastitis, Cancer and Homeopathy, Breast Cancer Facts, Cancer Facts, Cancer, Breasts - Structures and Types, Breast Lumps
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