New Warning Signs That may Predict Kidney Transplant Failure Revealed

by VR Sreeraman on  September 3, 2010 at 5:24 PM Organ Donation News   - G J E 4
A new study has suggested that kidney transplants that show a combination of fibrosis (scarring) and inflammation after one year are at higher risk of long-term transplant failure.
 New Warning Signs That may Predict Kidney Transplant Failure Revealed
New Warning Signs That may Predict Kidney Transplant Failure Revealed

The researchers analyzed factors related to transplant survival in 151 patients who had no apparent problems after living-donor kidney transplantation.

One-year biopsies showed no abnormalities in 57 percent of kidneys; another 30 percent had fibrosis (scarring) but no inflammation. In these two groups, the transplanted kidney continued to function normally from one to five years' follow-up.

However, in the remaining 13 percent of transplants, the biopsies showed fibrosis plus inflammation. These transplants had declining kidney function and a reduced long-term survival rate. Kidneys showing fibrosis plus inflammation also had increased numbers of immune cells as well as a "rejection-like" gene expression signature.

Thus, in apparently normal kidney transplants, biopsies showing fibrosis and inflammation signal kidney damage and an increased risk of long-term failure. "It is likely that the intragraft environment of patients with fibrosis and inflammation is damaging to the allograft," says Stegall.

Without routine "protocol" biopsies, these warning signs would go undetected until clinical abnormalities developed, comments Mark D. Stegall, MD (Mayo Clinic, Rochester, MN).

"The use of protocol biopsies allows for more detailed investigations of the intragraft environment," he says.

"Such routine biopsies could provide a unique way to predict which kidney transplant recipients may be at increased risk for loss of kidney function, or to identify potential targets for early preventative treatment."

The study appears in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

Source: ANI

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i am akidney transplant recipiant and i'm lookin at loosing my kidney in a yr maybe less i have had my transplant for 20 yrs and its the longest living one known ..the transplant comming up will be my 3rd n the 1st one was alive doner and the second was a cadaver which lasted 20 yrs just found this out for sure that i don't have inflamation on the kidney just scaring and thats due to age anmd meds
seabreeze Thursday, March 24, 2011

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