Medindia

X

New Therapies for Chronic Pain Possible With Novel Discovery

by Thilaka Ravi on  September 9, 2010 at 12:37 PM Research News   - G J E 4
A major mechanism underlying the development of tolerance to chronic morphine treatment discovered by Mount Sinai researchers might lead the way for new therapies to treat chronic pain.
 New Therapies for Chronic Pain Possible With Novel Discovery
New Therapies for Chronic Pain Possible With Novel Discovery
Advertisement

Developing tolerance towards morphine after chronic administration is a hurdle in pain management, but it also poses other problems, such as addiction and constipation.

Advertisement
Now researchers have identified how they can block this tolerance to treat pain with fewer side effects.

Lakshmi Devi and her colleagues found a protein complex that excessively accumulates in areas of the brain that process pain - which may be the cause of the development of morphine tolerance.

Their next step would be to develop a drug that prevents this process by blocking individual receptors from signalling the analgesic response to morphine.

"We look forward to studying the behaviour of similar receptor complexes in diseases like obesity, alcohol-induced liver fibrosis, and neuropathic pain itself," said Devi.

The findings are published in the July 20th issue of Science Signaling.

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All

More News on: