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New Target for Male Contraception Identified
But actually sperm's motility is in fact short lived. When in the male reproductive tract they have to rest easy, lest they wear themselves out prematurely and give up any chance of ever finding an egg.
Scientists have long known that sperm's activity level depends on their internal pH. And now -- after many years of looking researchers reporting in the February 5th issue of the journal Cell, a Cell Press publication, have finally found the channel that allows the tiny cells to rid themselves of protons. Once in the female reproductive tract, that proton release changes their internal environment from acidic to alkaline and begins their race to the finish line.
The findings offer new insight into a critical event in human fertilization and may lead to new ways of controlling male fertility, according to the researchers.
"The concentration of protons inside the [sperm] cell is 1,000 times higher than outside," said Yuriy Kirichok of the University of California, San Francisco. "If you just open a pore, protons will go outside. We identify the molecule that lets them out."
Kirichok likens the quiescent sperm cells to balloons inflated with protons instead of air. If you open a hole in the sperm, protons will readily flow out. In fact, each sperm's flagellum is covered in many so-called Hv1 proton channels, they show. When the channels are activated by external cues, the flood gates open and protons escape from many pores at once.
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