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New Target Identified For Age-related Macular Degeneration

by Tanya Thomas on  June 17, 2009 at 9:56 AM Research News   - G J E 4
 New Target Identified For Age-related Macular Degeneration
A new target has been identified by scientists for the diagnosis and treatment of age-related macular degeneration.
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In a study, researchers at the University of North Carolina at Chapel Hill School of Medicine in collaboration with lead investigators at the University of Kentucky have demonstrated that blocking the activity of a specific protein - called CCR3 -- can reduce the abnormal blood vessel growth that leads to macular degeneration.

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Also, targeting this new protein may prove to be safer and more effective than the current treatment for the disease, which is directed at a protein called vascular endothelial growth factor or "VEGF."

According to the researchers, the discovery - made in mouse models and cultured human cells - may also enable physicians to catch the disease in its earliest stages, before blood vessels have fully infiltrated and destroyed the central portion of the eye's retina-an area known as the macula-to cause vision loss.

"It would be much better to prevent the disease in the first place," said study co-author and principal investigator of the UNC study site, Mary Elizabeth Hartnett, M.D., a professor of ophthalmology in the UNC School of Medicine.

"An exciting implication of this study was that the CCR3 protein could be detected in early abnormal blood vessel growth, giving us the opportunity to prevent structural damage to the retina and preserve vision," Hartnett added.

Age-related macular degeneration (AMD) is currently treated with drugs that block the effects of VEGF, a growth factor that promotes the growth of abnormal blood vessels.

However, because this factor is also involved in the growth and health of normal blood vessels, concerns have been raised about the safety of its long-term use. To date, however, these anti-VEGF agents have been found to be safe.

Thus, the researchers sought to identify a new target for treatment that is specific to AMD. They detected the presence of the CCR3 protein in eye tissue from humans with AMD but not in that of individuals of similar age who did not have the disease.

When they blocked CCR3, either with drugs or through genetic engineering, they saw a decrease in the generation of abnormal blood vessels.

Drugs targeting CCR3 were significantly more effective than those targeting VEGF, meaning this could represent a new therapy for the two-thirds of patients that do not respond to current treatment.

The study has been published online June 14, 2009 by the journal Nature.

Source: ANI
TAN
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