Tumor suppressor genes make proteins that help control cell growth. Mutations in these genes that generate nonfunctional proteins can contribute to tumor development and progression. One of the most well-known tumor suppressor genes is BRACA1, mutations in which are linked to breast cancer.
Ze-Guang Han and colleagues, at the Chinese National Human Genome Center at Shanghai, People's Republic of China, have now identified SCARA5 as a candidate tumor suppressor gene in human hepatocellular carcinoma (HCC), a form of liver cancer that is the fifth most common cancer worldwide.
Alcoholic Liver Disease - Causes Symptoms Diagnosis Treatment FAQs
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease.
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease.
In the study, analysis of HCC tissue samples indicted that SCARA5 was frequently subjected to genetic loss and epigenetic silencing and that SCARA5 protein downregulation was most marked in HCC tissue samples characterized by tumor invasion into the blood vessels (a sign of aggressive disease).
Further analysis in HCC cells lines in vitro and after xenotransplantation into mice were consistent with SCARA5 being a tumor suppressor gene. The authors therefore suggest that SCARA5 protein downregulation as a result of SCARA5 genetic loss and epigenetic silencing can contribute to HCC tumor development and progression.
Liver Cancer
Liver is the largest organ inside the human body. It performs 500 different functions and processes 720 liters of blood per day. The important functions of the liver, the development of liver cancer and it’s symptoms are presented in this interactive.
Liver is the largest organ inside the human body. It performs 500 different functions and processes 720 liters of blood per day. The important functions of the liver, the development of liver cancer and it’s symptoms are presented in this interactive.
SRM
Liver Cancer Treatment
Liver Cancer is the uncontrolled growth of cells in the liver. The present section provides a graphic description of the various forms of liver cancer treatment in addition to the latest techniques such as Chemoembolisation and Radio frequency Ablation.
Liver Cancer is the uncontrolled growth of cells in the liver. The present section provides a graphic description of the various forms of liver cancer treatment in addition to the latest techniques such as Chemoembolisation and Radio frequency Ablation.
Cancer Key Facts and Statistics
Cancer is an abnormal cell growth and it can destroy other body tissues. 1 in 6 deaths that occur in the world is due to cancer. Here are some key facts and statistics about cancer
Cancer is an abnormal cell growth and it can destroy other body tissues. 1 in 6 deaths that occur in the world is due to cancer. Here are some key facts and statistics about cancer
