The NICU is a complex medical environment where the priority is on saving the lives of premature, sometimes critically ill infants. While the focus is on emergency respiratory, pulmonary, and nutritional interventions, the act of breastfeeding may be ignored or overlooked.
The SPIN program at UC San Diego Medical Center has set up a supportive environment where mothers are encouraged to pump milk around the clock. Frequent pumping keeps up the milk supply until the preemie achieves a coordinated sucking and swallowing reflex. For the mothers, this means pumping the milk every two hours, twenty-four hours a day. Support includes ergonomic assessments of the mother's feeding positions, educational flashcards with breastfeeding tips, emotional and nutritional support, and education for fathers or life partners.
Once the milk is pumped, the liquid is labeled with the family name and a unique identification number and scanned into a database. The SPIN program is developing quick and simple methods of measuring the nutritional content of human milk using a special near-infrared analyzer that is traditionally used in the dairy industry to determine the nutritional content of cow's milk. The analyzer in UC San Diego's NICU has been calibrated for human milk. Daily milk samples are now being analyzed for nutritional values such as calories, fat, protein, and lactose to help the medical team determine the ideal amount of nutrient supplementation to add to mother's milk.
"Human breast milk is considered human tissue and is full of carbohydrates, lipids, vitamins and minerals. There are approximately 300 components to breast milk including small biologically active compounds that aid in the formation of the gastrointestinal tract," said Kim. "The contents vary dramatically from mother to mother and feeding to feeding depending on the baby's needs."
Following identification, the SPIN team evaluates the best way to get the milk into the baby. Different aspects of manual feeding are tested such as the optimal size of the syringe and temperature of the milk. Knowing the exact chemistry of the milk, it can be accurately fortified to aid the child in his or her growth. Supplementation is currently done with both cow- and human-based milk fortifiers.
"We plan to look for correlations between the mother's diet and the nutritional characteristics of the breast milk. We may be able to identify certain foods and supplements that aid in the infant's growth and development," said Stellwagon.
Infants born prematurely sometimes develop an infection called necrotizing enercolitis (NEC), the most common life-threatening gastrointestinal emergency in the newborn period. NEC causes intense inflammation and acute intestinal necrosis or death. Approximately 7% of the smallest preemies develop this infection and 1/3 of these babies die. NEC compromises 1-5% of all NICU admissions and affects 10% of infants born at less than three pounds.
"Fortunately, breast milk contains enzymes that help protect against NEC," said Kim, an expert in short bowel syndrome and intestinal failure. "Babies born at one pound have their intestinal development in place but all things attributed to function are either at the earliest phase or have not kicked in at all. Breast milk has growth factors that affect the ability of the gut to grow and can get the digestion process on track to prevent this dangerous infection."
"Every second counts for the growth rate of infants, especially in the first days when babies are gaining up to 20 grams per kilogram of weight per day," said Kim. "The brain increases 5% in size every 48 to 72 hours. Adequate and extra nutrients can improve brain growth which is something the SPIN program is measuring."
With the SPIN program, the brain development of the infants is calculated by either measuring the circumference of the infant's head or performing MRI exams. These infants will receive developmental testing during follow-up visits to the NICU.
"Human milk provides benefits that are both nutritional and neurological," said Stellwagon. "In our life time, we will not be able to replicate its biological complexities. Until that day, the best thing for all newborns is breast milk. The SPIN program will help us learn how and why for preemies."
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