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New Study Unravels Cancer Cells' Affinity With Sugar
They say that their research may be useful for scientists in charting a mechanism that may lead to better cancer treatments.
Working under the guidance of Assistant Professor Jeffrey Rathmell in the Duke Department of Pharmacology and Cancer Biology, graduate student Jonathan Coloff found that the tumour cells use glucose sugar as a way to avoid programmed cell death.
While making a presentation at the American Association of Cancer Research Annual Meeting in San Diego on Tuesday, the researchers said that lab experiments showed that tumour cells make use of a protein called Akt to promote glucose metabolism, which in turn regulates a family of proteins critical for cell survival.
In normal cells, the removal of growth factors that regulate metabolism and cell survival leads to loss of glucose uptake and metabolism and cell death.
However, cancer cells maintain glucose metabolism and resist cell death, even when deprived of growth factors.
Coloff and his colleagues studied how Akt might affect these processes.
The researchers introduced a cancer-causing form of Akt, known as myrAkt, into cells that depend on growth factor to survive.
The mutant form of Akt allowed cells to maintain glucose usage, and survive even when no growth factors were present, allowing them to bypass a normal safeguard used by cells to prevent cancer development.
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