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New Study Raises Hope for Needle-free Diabetes Treatment
Found in 30 percent of all human cancer tumours, the Ras protein literally 'drives cells crazy,' says Prof. Yoel Kloog, the dean of the Faculty of Life Sciences at Tel Aviv University.
Kloog was the first in the world to develop an effective anti-Ras drug against pancreatic cancer, currently in clinical trials.
And now, Kloog's student Adi Mor of TAU's Department of Neuro-biochemistry and Sackler School of Medicine has modified the anti-Ras FTS compound to develop what could be the first tablet-based treatment for children and adults with Type 1 diabetes.
Early results have shown that FTS is effective in restoring insulin production in animal models.
And given the drug's history - FTS has already passed toxicity studies for other diseases and disorders - it has the potential to fast-track through FDA regulatory hurdles, skipping straight to Phase II clinical trials.
A new drug for diabetes could be ready in as little as five years' time.
Previous studies by Kloog's lab found that the FTS compound is effective against autoimmune diseases such as multiple sclerosis and lupus, "but the mechanism of its effects on immune cells was not well understood," says Mor.
"I wanted to see if there was a connection between Ras and the regulation of the immune system, and if so if FTS could help regulate it to prevent or slow diabetes," Mor added.
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