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New Study Finds Biological Pathways for ALS Progression
ALS is sometimes also called Lou Gehrig's disease.
In the study, blood samples from more than 220 ALS patients at the Methodist Neurological Institute were used in research that revealed significant changes in or around 10 specific genes in sporadic ALS.
This discovery has helped identify new biological pathways for the progression of ALS in individuals with this debilitating disease, said Dr. Stanley Appel, chair of the department of neurology at The Methodist Hospital and co-founder of the Methodist Neurological Institute in Houston.
ALS is most likely caused by a combination of environmental and genetic components. This type of study provides us with a better understanding of the genetic contribution, he added.
Sporadic (non-inherited) ALS affects 90 percent of the ALS population. This population is representative of the patients at the MDA/ALS Clinic and Research Center at the Methodist Neurological Institute, the first and one of the largest multi-disciplinary ALS clinics in the nation.
Our incredible, courageous patients were able to personally contribute to our quest to find a cure for ALS by providing their own blood toward our joint mission, said Appel, co-author of the paper. I hope that our work honours them with real results that can improve their lives and the lives of those who might some day be cured of ALS, he said.
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