Scientists in the Bangalore-based Stempeutics Research say mesenchymal stem cell (MSC) therapy could make life a lot better for those injured in their spinal cords.
A pilot study conducted by the southern Indian research institution has shown promising results.
The MSCs were injected directly into the spinal cord of the patient for maximum efficacy. It was injected either intra-arterially or through intra-spinal (site of injury) route. This new technique of injecting of stem cells close to the site of injury showed good results.
"This is the first time anyone has tried injecting stem cells directly into the injured area. And we got good results," says Dr Sujay Rao, consultant neurosurgeon, St Philomenas Hospital, Bangalore. "This system maximises the yield of stem cells. The chances of loss in the bloodstream is minimised," Rao explains.
Traditionally, stem cells have always been injected either through intravenous drips or through lumber puncture directly into the cerebo-spinal fluid. But when injected this way, the stem cells float around the body or in the blood stream. Very few of them reach the target. Moreover, in case of spinal cord injuries, the adjoining tissues let out a signal called cytobine signals, which attract stem cells from other parts of body to heal the injury.
But in case of an old injury, these signals are not let out anymore. Therefore, the stem cells that are injected in the body through the traditional method may not get attracted to the injury at all. The new method takes care of all this. Here MSCs are injected directly into the injury for maximum effect. These can create tissues or cartilage or bones as required by the injury and repair it, writes Sujata Dutta Sachdeva in Times of India.