Only two approved U.S. and Russian labs keep known stockpiles of smallpox, which the CDC considers among the greatest potential threats to public health.
"Smallpox could be a particularly dangerous biological threat to us that would kill or debilitate a high percentage of the population," said Dr. W. Craig Vanderwagen, a rear admiral and assistant secretary for preparedness and response at the Department of Health and Human Services.
Smallpox is caused by the variola virus, which spreads through close contact with infected individuals or contaminated objects. There is no FDA-approved treatment for it.
The new vaccine is derived from the nation's old smallpox vaccine, called Dryvax, which is no longer made, although there are leftover supplies. ACAM2000 is made using a pox virus called vaccinia, which is related to but different from the virus that causes smallpox.
It contains live vaccinia virus, the FDA said, and works by causing a mild infection that stimulates an immune response that effectively protects against smallpox without actually causing the disease.
Source-Medindia
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