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New Skin Cancer Drug Shrinks Tumours: Scientists
A team of US researchers said some melanoma patients in the trial saw a dramatic improvement in their condition and hailed the findings "a huge step forward."
"We are very excited about these results," said Dr Paul Chapman, involved in the research at the Memorial Sloan-Kettering Cancer Center in New York.
"We are seeing some pretty dramatic and rapid responses," he added.
The trial results, presented on Thursday at a major cancer conference in Berlin, showed some patients treated with the PLX4032 drug twice a day had seen their tumours shrink.
Thirty-one advanced melanoma sufferers with a cancer-causing gene mutation were involved in the trial.
Of 22 patients so far evaluated, tumours in 20 of them had reduced in size, according to Dr Chapman.
Melanoma is not the most common skin cancer but is one of the most difficult to treat successfully once it has started to spread, researchers said.
The drug in the trial works by blocking the activity of a mutation of the BRAF gene, which is thought to play a role in half of melanoma cancers.
Dr Chapman said the study was impressive as most of the patients, all of whom had the BRAF mutation, had already failed to respond to several previous treatments.
"A lot of these patients were pretty sick but many of them had a significant and rapid improvement in the way they function," he said.
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