They found that genetic instability in the mouse cancer cells resulted in DNA alterations that were identical to similar changes in human tumors in many cases. This similarity suggested that the new mouse model might be useful in steering the search for genes that are crucial for cancer growth.
The mouse model's close resemblance to human T-ALL made it possible for the scientists to identify two genes, FBXW7 and PTEN, to be commonly deleted or mutated in this type of human cancer.
"We found a rather striking overlap of genetic alterations in the mouse and human cancers, which should greatly help us sort out genetic events that drive cancers from those that are simply irrelevant 'passenger' events," DePinho said.
Researchers concluded that the over lining patterns of genetic abnormalities in mouse and human tumors showed that cancer mechanisms in the two species are more alike than earlier thought.
The findings of the study were published online in the journal Nature.
Source-ANI
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