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New Models may Help With Effective Treatments for Fractures
Results of the model may benefit the ageing population in which the occurrence of bone fractures is expected to rise substantially in the near future.
In 5 to 10 percent of bone fracture cases, the healing process does not succeed in repairing the bone, which leads to the formation of delayed unions or even non-unions - fractures that fail to heal.
Using a combination of an animal model mimicking a clinical non-union situation and a mathematical model developed for studying normal fracture healing, researchers at the Katholieke Universiteit Leuven (Belgium), University of Lihge (Belgium), Edinburgh University (United Kingdom) and Oxford University (United Kingdom) investigated this health problem.
For example, the authors investigated the potential to treat non-unions by transplanting cells from the bone marrow to the fracture site.
This was also tested in a pilot animal experiment; both the simulations and the experiments showed the formation of a bony union between the fractured bone ends.
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