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New Methods to Screen Alzheimer's Drugs
The researchers found that brain cells exposed to a form of the amyloid beta protein, the molecule linked to Alzheimer's disease, become stiffer and bend less under pressure.
The team, led by Gang-Yu Liu, professor of chemistry, and Lee-Way Jin, associate professor of pathology and a researcher at the UC Davis Alzheimer's Disease Center, used a cutting-edge microscope to measure how cells respond to physical pressure.
The microscope, located at UC Davis' Spectral Imaging Facility, combines an atomic force microscope and a confocal microscope. It is one of a handful in the United States and one of the most advanced of its type, Liu said.
An atomic force microscope uses a fine needle to visualize the features of a surface with exquisite resolution and precision; it is used more often in materials science than in cellular biology.
A confocal microscope can view living cells in culture media and in three dimensions.
The team put a glass microbead on the tip of the AFM needle and used it to press down on living cells.
By measuring the forces required to squeeze the cell under the bead, they could calculate the stiffness of both the cell membrane and the cell contents.
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