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New Drugs Other Than Antibiotics to Fight TB, Bacterial Infections Identified
It was suggested by researchers that exciting new molecular targets known as "virulence factors" used by bacteria to thrive once they are in the host, present an alternative, potent means of stopping TB, leprosy and other bacterial illness.
The study was led by Dr. Luis Quadri, Associate Professor of Microbiology and Immunology at Weill Cornell.
"We have developed the first inhibitor of a key small molecule from Mycobacterium tuberculosis and Mycobacterium leprae (which causes leprosy) utilized to subvert human host's defenses and damage and invade human host's cells during infection," he said.
He added: "With this work, we now have proof of principle for the inhibition of this virulence factor in bacteria cultured in the lab. Our next step is to explore whether this inhibitor can stop these pathogens from multiplying in a mouse host, curtailing infection.”
According to Dr.Quadri, the study’s findings highlight a "paradigm shift" in infectious disease research.
"We are moving beyond antimicrobials such as antibiotics, which kill the bacterium directly, to anti-infectives, that may have no effect against the pathogen in the test tube but which do compromise its ability to infect and spread in the host," he explained.
During the study, the researchers’ primary focus was on particular small-molecule virulence factors called phenolic glycolipids (PGLs).
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